NYU Data Catalog

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  • NYU Dataset

    Immune Responses Observed Before and After BNT162b2 mRNA Vaccine Administration in Individuals with and without History of SARS-CoV-2 Infection

    Authors
    Marie I. Samanovic
    Amber R. Cornelius
    Sophie L. Gray-Gaillard
    Joseph Richard Allen
    7 more author(s)...
    Description

    To study and compare longitudinal immune responses to two-dose BNT162b2 mRNA vaccinations, investigators recruited 15 adults with a history of laboratory-confirmed COVID-19 and 21 adults who did not have COVID-19. Participants' ages ranged from 21 to 65 years old. Peripheral immune responses were assessed via blood samples drawn before and after each vaccine dose. A total of five samples were collected...

    Subject
    COVID-19
    Infectious Disease
    Timeframe
    2021
    Access Rights
    Free to All
  • NYU Dataset

    Spatial Transcriptomics Stratifies Psoriatic Disease Severity

    Authors
    Rochelle L. Castillo
    Ikjot Sidhu
    Igor Dolgalev
    Tinyi Chu
    21 more author(s)...
    Description

    This study described human psoriasis (PsO), which is a prototypic immune-mediated condition with a high predilection for extra-cutaneous involvement. Although the cellular and molecular features of human inflammatory skin diseases have been identified, their tissue context and systemic impact remains unclear. Spatial transcriptomics was performed to explain the cellular landscape of both healthy and...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    MicroRNA-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques

    Authors
    Milessa Silva Afonso
    Monika Sharma
    Martin Schlegel
    Coen van Solingen
    11 more author(s)...
    Description

    MicroRNA-33 (miR-33) targeted inhibition increases plasma HDL cholesterol and promotes atherosclerosis regression by enhancing reverse cholesterol transport and dampening plaque inflammation. This study showed how miR-33 inhibition alters the dynamic balance and transcriptional landscape of immune cells in atherosclerotic plaques. They used single cell RNA sequencing of aortic CD45+ cells, combined...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection

    Authors
    Ellie Ivanova
    Jasmine Shwetar
    Joseph C. Devlin
    Terkild B. Buus
    17 more author(s)...
    Description

    To investigate immune responses to SARS-CoV-2 antigens under various inflammatory conditions, researchers collected blood samples from five adult patients seen at NYU Langone Health with lab-confirmed cases of acute COVID-19 and from nine healthy adults (seven who had received the BNT162b2 mRNA vaccine and two with no prior exposure to SARS-CoV-2). Samples were obtained at multiple time points. Patients...

    Subject
    COVID-19
    Genomics
    Infectious Disease
    Access Rights
    Free to All